I actually have a long history of migraine headaches, and have tried many things to get rid of them. The first prophylactic intervention was a blood pressure medicine, but seeing as I have low blood pressure usually, it basically made me sleep 18 hours a day... after which I usually woke up with a dull aching in my head.
And then there was the Topomax, which was one of the worst experiences of my life. I trogged through days of crying hysterically at insanely stupid things (like not being able to find my keys in my purse and then realizing that my husband had used them and I would have to walk back inside to get them), not being able to drive at all because I was too spaced out, scaring the hell out of my family with aggressive behavior that I don't recall at all, and then the proverbial straw on the back of a overloaded camel, forgetting how to walk.
I guess you would call it forgetting how to walk... I came out of the bathroom walking just fine, I abruptly stopped and then I was standing there, a few steps from the end of my bed, trying to will myself to walk forward and lay down and my brain's answers was, "Nope, I don't believe we will be doing that." So I stood there, swaying, while my husband tried to figure out what the hell I was doing, and had a silent conversation in my head trying to convince my brain to let me move, that sounded like this:
Me: Uh, I'd like to lay down now...
Me: No really, let's lay down.
Brain: Yeah... no.
Me: But this is really easy, just go forward, bend at knees, plop onto bed?
Brain: Yeah... not gonna happen.
Me (thinking): I could just flop onto the bed and be done with this foolishness...
Brain: You know I can hear you, right...?
Somehow I indicated to my husband what was happening and he came and helped me lower myself onto the bed. At that moment, an executive decision was made that being able to move at will was really important to me and I would no longer be taking devil drugs to prevent migraines.
At the most now, I lose several hours a day to sitting in dark rooms and crying that my brain is being hacked apart while I wait for my medications to kick in. I find though, that it is a far sight better than being completely useless 24 hours a day from drugs that are designed to stop me from having a few hours of pain.
Note: My doctor is convinced it is just migraines though I've had no MRIs or CAT scans w/ contrast (because I have no insurance so they avoid those expensive tests, though I think I'll be forcing the issue next month when I see her)... but it is not vision problems, or blood pressure. And it is not caffeine or lack of caffeine, or diet, or exercise... changing all of those things makes no difference at all... my brain is just an asshole... or there is a crazed woodsman in there.