Beyond that, I tend to think very literally sometimes, which is fairly apparent in my humor stylings.
As a result, I have a hard time not being a psychic jerk to people who stand on the side of the roads panhandling, when they have stupid signs. By psychic jerk, I mean I don't actually antagonize real people, but I fantasize about it, because being a jerk in real life sucks but in your imagination, it is awesome.
The sign that bothers me most is the "ANYTHING HELPS!" sign.
I think you really need to be specific about what ACTUALLY helps. If I ever find myself in a situation where I need to beg for money on the side of the road, I already have my sign planned.